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Ovulation Induction


Fertility drugs often referred , and used to stimulate the process of the follices in the ovaries , which results in the production of multiple eggs in one cycle. Medications also control the time that you release the eggs, or ovulate, the certain procedures that can be scheduled,like sexual intercourse, intrauterine insemination’s and in-virto fertilization that can help achieve pregnancy.

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n the course of ovulation induction there are certain risks involved, considering medications that include an increase the change of high order multiple births, and also development of ovarian cysts. There is a very rare side effect which can occur which is ovarian hyper-stimulation syndrome (OHSS), the symptoms are diffculty in breathing, increase in weight, severe pain in the pelvis, abdomen & chest, nausea vomiting & bloating.Most commonly used fertility treatment are clomiphene citrate, gonadotropins, Metformin and Parlodel.

CLOMIPHENE CITRATE (CLOMID, SEROPHONE)- Is used for women who have irregular periods and long menstrual cycles ,the side effects of this medication is headaches, hot flashes, and blurred vision, this medication is given in a tablet form.

Gonadotropins (Repronex, Follistim, Bravelle, Pergonal and GonalF)- This medication is used to induce the release of an egg once the follicles are developed and the egg matures,the side effects of this medication is abdominal discomfort mood swings,fatigue, restlessness,bloating sensation , these side effects are reduced and relieved by follicular aspiration. This medication is used like an injection.

Glucophage (Metformin)- It is widely used with patients with the disease of PCOS(polycystic ovary syndrome), this medication has shown to reverse the endocrine abnormalities with PCOS. Metformin is given to patients to decrease the insulin. The effects of Metformin are, decrease in facial hair and body hair growth,regulation of menses, normalization elevated blood pressure, and weight loss and normal fertility.

Parlodel- This medication is used to lower prolactin levels, it also reduced any pituitary tumor, that could be present, this medication is taken orally with food, it is said to be a few side effects, and this medication is relatively inexpensive.

Various levels of ovulation induction is used to treat infertility, related to ovulation disorders, with unknown cases or male factors. Clomiphene citrate(clomid or Serophene) that helps to treatment ovulation, the doctor prescribes the medication to be taken for 5 days at the beginning of the cycle. Mostly the percentage of patients under this medication who would ovulate is around 80% and around 50% of them would conceive . The drug Clomiphene, when combined with intrauterine insemination helps to boost the success of medication by placing the sperm and the egg in close proximity with each other.

SUPEROVULATION

Super ovulation is the most aggressive level of ovulation induction. This can be treated by the combination of gonadotropins and clomiphene to stimulate the production of multiple eggs, sometimes gonadotropin itself is used.

Patients who undergo supervoulation, most take extra care and closely monitored by blood tests and ultrasounds. The doctor needs to ensure that the patient does not hyper-stimulate

and the right dosage is administered, so that only a few follicles develop. This is critical as the pregnancy level needs to be controlled . When the super ovulationn treatment is over a mild dose of (HCG)human chorionic gonadotropin is administered to stimulate the ovulation. After around 24-36 hours of HCG administered, ovulation will occur. The doctor advises the patient to either have sexual intercourse or come to the clinic for an intrauterine insemination. The success rate per super ovulation , depending on the cause of infertility is around 10-20% approximately, depending on the age of the women.

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